{"id":539892,"date":"2023-07-03T22:40:04","date_gmt":"2023-07-04T04:40:04","guid":{"rendered":"https:\/\/staging-7b2a-cerebrodigitalnet.wpcomstaging.com\/investigadores-crean-modelos-de-embriones-humanos-utilizando-celulas-madre-eacr\/"},"modified":"2023-07-03T22:46:03","modified_gmt":"2023-07-04T04:46:03","slug":"researchers-create-model-human-embryos-using-stem-cells-eacr","status":"publish","type":"post","link":"https:\/\/staging-7b2a-cerebrodigitalnet.wpcomstaging.com\/en\/researchers-create-model-human-embryos-using-stem-cells-eacr\/","title":{"rendered":"Researchers Create Model Human Embryos Using Stem Cells"},"content":{"rendered":"\n

Four teams of scientists have made models of human embryos<\/a> that do not require an egg or sperm, they announced in June. While these \u201csynthetic embryos\u201d have raised questions about regulating this type of research, scientists hope the models will unlock answers about the early days of human development.<\/p>\n\n\n\n

\"-\"<\/figure>\n\n\n\n

After an egg and sperm cell fuse, the fertilized egg travels through the fallopian tubes to the uterus, while its cytoplasm divides into smaller cells. This ball of cells then attaches to the lining of the uterus.<\/p>\n\n\n\n

But scientists don\u2019t know much about what happens to the cells in the next couple of weeks. This period is \u201ctruly a black box,\u201d<\/em> Jacob Hanna, a co-author of one the new studies and a stem cell biologist at the Weizmann Institute of Science in Israel, tells Science\u2019s Mitch Leslie.<\/p>\n\n\n\n

Studying this phase of an embryo\u2019s development is difficult: Scientists can\u2019t easily observe it when it\u2019s developing inside a womb, and in the lab, several countries have laws against studying actual human embryos beyond 14 days after fertilization.<\/p>\n\n\n\n

\u201cWe sought to develop a tool to ask specific questions about the second week of human embryo development, since using actual human embryos in research is ethically and technically challenging,\u201d <\/em>Magdalena \u017bernicka-Goetz, a co-author of one of the new studies and a developmental biologist at the University of Cambridge in the U.K., tells Nature News\u2019 Philip Ball.<\/p>\n\n\n\n

Instead of using real embryos, researchers have begun creating models using human stem cells, which can develop into many different types of cells. In the new research, the scientists coax stem cells to grow into the components of embryos. The stem cells were grown in a lab, but they came from embryos originally, writes New Scientist\u2019s Clare Wilson.<\/p>\n\n\n\n

Hanna and \u017bernicka-Goetz, with their respective teams, worked on separate model embryos that demonstrate human development through 14 days after fertilization. Hanna\u2019s team\u2019s model contains membranes within and outside of the embryo, and \u017bernicka-Goetz\u2019s team\u2019s model displays tissues that could later create the placenta and yolk sac, writes Laura Ungar of the Associated Press (AP).<\/p>\n\n\n\n

The scientists want to use the models to study the period of development when many pregnancies fail, learn more about developmental disorders and provide insights into treatments for infertility and diseases. The stem cell embryos could also help researchers understand how organs develop or test drugs used during pregnancy.<\/p>\n\n\n\n

\u201cIf we can experimentally model this period [nine to 14 days after fertilization], then we can finally start asking questions about how human development happens in those very early stages that are normally hidden within the body of the mother,\u201d Berna Sozen, a study co-author and developmental stem cell biologist at Yale University, tells the AP.<\/p>\n\n\n\n

Versions of two of the papers were posted online last week in the journal Nature while they are still undergoing editing. The two other studies were posted earlier in June on the preprint server bioRxiv and have not yet been peer reviewed.<\/p>\n\n\n\n

This research remains controversial. For one, some scientists think the models are not yet practical representations of actual embryos.<\/p>\n\n\n\n

\u201cWhat we can see is masses of cells separated into compartments, but no embryo-like organization,\u201d <\/em>Alfonso Martinez Arias, a developmental biologist at Pompeu Fabra University in Spain who was not involved in the research, says to Nature News of the work by \u017bernicka-Goetz\u2019s team.<\/p>\n\n\n\n

\u201cThe work is in very early stages, and the current methods are far from reliable,\u201d Alysson Muotri, a developmental biologist at the University of California San Diego who did not contribute to the research, tells the New York Times\u2019 Carl Zimmer.<\/p>\n\n\n\n

Other scientists wonder about the ethics surrounding the use of model embryos.<\/p>\n\n\n\n

\u201cIf the whole intention is that these models are very much like normal embryos, then in a way, they should be treated the same,\u201d <\/em>Robin Lovell-Badge, a stem cell biologist at the Francis Crick Institute in the U.K. who wasn\u2019t involved in the research, tells the Guardian\u2019s Hannah Devlin. \u201cCurrently, in legislation they\u2019re not. People are worried about this.\u201d<\/p>\n\n\n\n

Previously, researchers have made synthetic embryos from mouse and monkey stem cells. But even with human stem cells, some scientists say the synthetic embryos help avoid the ethical minefield of using real, fertilized eggs.<\/p>\n\n\n\n

\u201cThey\u2019re complete enough to give you a picture of what may be happening in the embryo during pregnancy, but they\u2019re not so complete that you could actually use them for reproduction,\u201d<\/em> Insoo Hyun, an ethicist at Harvard Medical School who didn\u2019t contribute to the studies, tells the AP. \u201cIt just will not work.\u201d<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

Four teams of scientists have made models of human embryos that do not require an egg or sperm, they announced […]<\/p>\n","protected":false},"author":32,"featured_media":539888,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"two_page_speed":[],"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false,"jetpack_post_was_ever_published":false},"categories":[107085],"tags":[107228,109844,109845],"class_list":["post-539892","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","tag-embryos","tag-mother-cells","tag-synthetic-embryos"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/staging-7b2a-cerebrodigitalnet.wpcomstaging.com\/wp-content\/uploads\/2023\/07\/Investigador_celulas_madre_kjhg-triangle.jpg","jetpack_likes_enabled":false,"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/pgrue1-2grW","jetpack-related-posts":[{"id":535994,"url":"https:\/\/staging-7b2a-cerebrodigitalnet.wpcomstaging.com\/en\/the-first-babies-conceived-with-a-sperm-injecting-robot-have-been-born-eacr\/","url_meta":{"origin":539892,"position":0},"title":"The first babies conceived with a sperm-injecting robot have been born","author":"Andrey Robles","date":"April 25, 2023","format":false,"excerpt":"Last spring, engineers in Barcelona packed up the sperm-injecting robot they\u2019d designed and sent it by DHL to New York City. 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