{"id":536152,"date":"2023-05-07T22:54:27","date_gmt":"2023-05-08T04:54:27","guid":{"rendered":"https:\/\/staging-7b2a-cerebrodigitalnet.wpcomstaging.com\/la-fda-aprueba-la-primera-pildora-que-contiene-heces-humanas-eacr\/"},"modified":"2023-05-07T23:03:52","modified_gmt":"2023-05-08T05:03:52","slug":"fda-approves-first-pill-containing-human-feces-eacr","status":"publish","type":"post","link":"https:\/\/staging-7b2a-cerebrodigitalnet.wpcomstaging.com\/en\/fda-approves-first-pill-containing-human-feces-eacr\/","title":{"rendered":"FDA Approves First Pill Containing Human Feces"},"content":{"rendered":"\n

Patients needing a fecal microbiota transplant for recurrent Clostridioides difficile (C. diff) infections now have the option of getting<\/a> stool in pill form.<\/p>\n\n\n\n

\"-\"<\/figure>\n\n\n\n

Patients needing a fecal microbiota transplant for recurrent Clostridioides difficile (C. diff) infections now have the option of getting stool in pill form.<\/p>\n\n\n\n

The U.S. Food and Drug Administration (FDA) recently approved Vowst, the first oral biologic drug for fecal microbiota that was shown in clinical trials to be as effective as fecal microbiota transplants given rectally. Biologic drugs are derived from blood, proteins, bacteria, and other living organisms.<\/p>\n\n\n\n

In a traditional fecal microbiota transplant or FMT, healthy donor stool is transferred into the colon of a patient, usually via colonoscopy or retention enema. Late last year, the FDA approved the first microbiota product for rectal administration to C. diff patients.<\/p>\n\n\n\n

C. diff, often contracted by taking antibiotics, is highly a contagious bacterial infection that causes severe diarrhea, abdominal pain, and fever and can result in organ failure and even death. Recurrent infections within two to eight weeks are a problem for about one in six patients, according to the U.S. Centers for Disease Control and Prevention (CDC). Risk factors include recent hospital or nursing home stay, a weakened immune system, and previous C. diff infections.<\/p>\n\n\n\n

In response to the approval of the new oral microbiota product, Dr. Peter Marks, director of the FDA\u2019s Center for Biologics Evaluation and Research, said in a news release:<\/p>\n\n\n\n

\u201cThe availability of a fecal microbiota product that can be taken orally is a significant step forward in advancing patient care and accessibility for individuals who have experienced this disease that can be potentially life-threatening.\u201d<\/em><\/p>\n\n\n\n

New Product, New Risks<\/h2>\n\n\n\n

Vowst\u2014taken as a dose of four capsules for three consecutive days\u2014is not free of risk. The donated human fecal matter is screened for transmissible pathogens before it is manufactured. However, as the news release pointed out, there is a possibility that donor stool used in the pill could be infected with infectious pathogens, as well as food allergens. The potential for adverse reactions caused by Vowst due to such allergens is unknown.<\/p>\n\n\n\n

That\u2019s a potential concern, Dr. Sabine Hazan, gastroenterologist, CEO of ProgenaBiome, and expert on gut bacteria told The Epoch Times.<\/p>\n\n\n\n

\u201cAs much as we can solve one problem, we may be developing others,\u201d <\/em>she cautioned. \u201cWe have to be careful and monitor these patients carefully to make sure they don\u2019t develop other problems.\u201d<\/em><\/p>\n\n\n\n

The FDA news release noted that the drug was part of an application designated for a rapid review aimed at getting products to market quickly and was granted Priority Review, Breakthrough Therapy, and Orphan designations.<\/p>\n\n\n\n

There\u2019s no FDA-approved screening test for COVID-19 on the donor samples, Hazan said, so it\u2019s incumbent on the companies that collect donor stool and process it for transplants to do their own testing. The virus can be isolated on a forensics level.<\/p>\n\n\n\n

Another concern, she said, is that there\u2019s a reliance on the healthy status of donor stool, which isn\u2019t subject to any particular standard. In Hazan\u2019s practice, patients choose their own donors\u2014usually from among close family members if possible. All health conditions of the donors are considered and discussed.<\/p>\n\n\n\n

That\u2019s not to say the new pill cannot be successful. Hazan pointed out that the field of using poop to treat infections and diseases is a bit crazy, but the results with C. diff are some of the more impressive results seen.<\/p>\n\n\n\n

\u201cWe are advancing the field by approving this,\u201d<\/em> she said. \u201cHopefully it will do well and it\u2019s safe, and it doesn\u2019t cause any complications. Going from the clinical trials to the clinic are two different things.\u201d<\/em><\/p>\n\n\n\n

Trial Results<\/h2>\n\n\n\n

According to the FDA news release, in a U.S. and Canadian randomized, double-blind, placebo-controlled, clinical study of the safety of Vowst, 89 participants received Vowst and 93 received placebo treatment. CDI recurrence in Vowst-treated participants was 12.4 percent, compared to 39.9 percent in placebo-treated participants. The FDA also reported that Vowst recipients were more likely to report abdominal bloating, fatigue, constipation, chills, and diarrhea after treatment.<\/p>\n\n\n\n

Fecal transplants have become the gold standard treatment for C. diff recurrence, easing the persistent diarrhea that interrupts quality of life. FMT patients appear to retain diverse colonization in their guts, potentially for years.<\/p>\n\n\n\n

In recent estimates by the CDC, C. diff infects about 500,000 Americans each year. About 29,000 patients die within a month of the initial diagnosis, with 15,000 deaths directly attributed to the infection.<\/p>\n\n\n\n

C. diff typically results from antibiotic use, which lowers immune resistance to infections when the good bacteria are removed from the gut, creating an imbalance of bacteria called dysbiosis. About half of C. diff infections come from hospitals where the tenacious bacteria is difficult to kill.<\/p>\n\n\n\n

\u2018Proof of Concept\u2019<\/h2>\n\n\n\n

Though it appears it\u2019s the good bacteria that make fecal transplants effective, scientists don\u2019t know for certain why they work so well, according to Dr. Neil Stollman, chairman of gastroenterology at Alta Bates Summit Medical Center. He predicted at the February Malibu Microbiome Meeting that the next FDA-approved fecal microbiota product would be for C. diff infections.<\/p>\n\n\n\n

\u201cReally C. diff is our proof of concept of [dysbiosis]. We have an illness caused by dysbiosis that we can reliably cure by transplanting healthy stool, and I think that\u2019s absolutely extraordinary,\u201d <\/em>Stollman said.<\/p>\n\n\n\n

Many diseases are linked to dysbiosis, and researchers are predicting a \u201cbugs as drugs\u201d era with many biologics in development. Stollman said a quick scan of the PubMed database that houses research from around the world turned up studies using fecal transplants for more than 200 conditions.<\/p>\n\n\n\n

\u201cI\u2019m more excited and interested in the fact that this is a tiny little window for a much bigger conversation about bacterial therapy and targeted biome restoration,\u201d <\/em>he said.<\/p>\n\n\n\n

Hazan believes colonoscopy is the better delivery system for a transplant since the home for most of the gut bacteria is the cecum, the widest part of the large intestine.<\/p>\n\n\n\n

In a procedure that is as personal as introducing someone\u2019s stool into your body, Hazan said conversations about the donor are a vital part of the process. She said there\u2019s already evidence of obesity, hair growth, food cravings, and mental health being altered with the procedure.<\/p>\n\n\n\n

\u201cLet\u2019s be honest, you\u2019d rather have poop from your family than a complete stranger,\u201d <\/em>Hazan said.<\/p>\n","protected":false},"excerpt":{"rendered":"

Patients needing a fecal microbiota transplant for recurrent Clostridioides difficile (C. diff) infections now have the option of getting stool […]<\/p>\n","protected":false},"author":32,"featured_media":536148,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"two_page_speed":[],"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"{title}\n\n{excerpt}\n\n{url}","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false,"jetpack_post_was_ever_published":false},"categories":[107106,107208],"tags":[108887,108888,108889,108893,107225,108890,108891,108894,108892],"class_list":["post-536152","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","category-social-science","tag-clostridioides-difficile-en","tag-fda-en","tag-heces-humanas-en","tag-human-feces","tag-humans","tag-pastillas-en","tag-pildoras-en","tag-pills","tag-tablets"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/staging-7b2a-cerebrodigitalnet.wpcomstaging.com\/wp-content\/uploads\/2023\/05\/pildoras_de_heces_jkhg-mitchell.jpg","jetpack_likes_enabled":false,"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/pgrue1-2ftC","jetpack-related-posts":[{"id":536146,"url":"https:\/\/staging-7b2a-cerebrodigitalnet.wpcomstaging.com\/la-fda-aprueba-la-primera-pildora-que-contiene-heces-humanas-eacr\/","url_meta":{"origin":536152,"position":0},"title":"La FDA aprueba la primera p\u00edldora que contiene heces humanas","author":"Andrey Robles","date":"May 7, 2023","format":false,"excerpt":"Los pacientes que necesitan un trasplante de microbiota fecal para infecciones recurrentes por Clostridioides difficile (C. diff) ahora tienen la opci\u00f3n de recibir heces en forma de pastillas. 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